Rapamine can extend throughout the lifetime by avoiding damage to DNA

The anti -aging effects of drug reimscin can at least be partly due to preventing DNA damage in our immune cells. This is an understanding that can help us to remove his ability as an extension of life.

Originally developed as an immune pressure for people under organ transplantation, Rapamine has stopped the action of MTOR protein, which is key in the development and distribution of cells. In low doses, it has been shown that animals such as flies and mice increase throughout the lifetime, possibly interfere with the process that leads to aging symptoms, such as inflammation, cellular disorders and low function of microidia that strengthen our cells.

Now, Lin Cox and his colleagues at the University of Oxford have found that Rapamine also prevents DNA damage in a type of immune cell. DNA damage is a major driver of our immune system aging, which accelerates aging throughout the body.

Researchers revealed it when treating human immune cells called T -sales, a type of white blood cells that fight infection, with rapamine, when they were also brought before antibiotics called Zeusen, causing DNA damage.

He found that Rapamyson damaged DNA and increased the survival rate of cells three times, compared to Zusen only.

Researchers have not seen any evidence that it has resulted in any other effects of rapemine, such as preventing cellular malfunction. “Whether you use rapemicin during loss or loss during loss or after loss, we always see this mechanical effect,” says teammate at Oxford University.

The speed of the effect also shows that it is directly. “The effect is so quick, it seems that it affects the reaction of DNA damage and its accumulation [DNA] Cox says, wounds within about 4 4 hours, so I don’t think it can be the result of other things being affected.

The study supports Rapamine, which has a direct safety effect on DNA, but “reduces a final procedure,” says Matt Keberlen at Washington University in Seattle. Researchers hope that the RNA and protein produced in immune cells will be investigated by investigating the induced changes.

In another section of the study, they took nine men, aged between 50 and 80 years, to take 1 milligrams daily in Rapidamin or Placebo. After eight weeks, blood tests suggest that men’s T cells on Rapamine have less damaged DNA. There was no reduction in the total number of white blood cells in any group, which shows that rapemicin does not negatively affect the immune function. “We have shown that it is not harmful in small quantities, and this is an important point,” says Cox.

Cox says, dealing with DNA damage to immune systems can lead to a way to reduce the overall age. And Rapamine can also be used with prevention, perhaps to remove DNA damage to astronauts in the face of cosmic radiation.

“Rapamine can be especially useful for aspects of aging where DNA loss is a primary driver, such as skin aging,” says Caberlin. But he added that since Cox’s team’s experiences used antibiotics to cause DNA damage, other reasons, such as radiation, should be careful to promote damage.

Sultanawa, located at the University of East England, the UK, has noted that since the Placebo -controlled experience was done only on old men, it is important to test women and people of different ages. Studies in inhumane animals show that rapemine can have sexual and age -related effects.