Today’s guest authors are Marcos T Olivira (University of D. Sao Paulo), Nathan R. Rodrigus (University of D. Sao Paulo), Ricardo GP Ramos (University of D. Sao Paulo), and Gulam Olivira Barbosa (University Statidal de Camnez).
In Brazil, it is expensive to do science, and get more every year. Most Regents are imported, which are subject to exchange rates, delays in customs and often tax. Many labs, especially the newly established individuals, face these pressures daily constant challenges.
We represent Brazil Druzofla Melanogaster Researchers, who independently decided to use this model system in our own labs, on all career stages to get the biological questions of our interest. We have been able to do meaningful biological and biomedical research despite the budget barriers. In the past, six Noble Rewards in physiology or medicine have been given to scientists using this fruit bee for ground breaking discoveries. We firmly believe that adopting this low cost, high impact, Nobel Laureate model widespread resources -affected settings can help many people get competitive in global research landscapes.
“Low cost” what does it mean to deny
Low cost is lured to connect with low impact or low quality. But in the case of DruzoflaAffording is a feature, no flaws. Bees experiments are estimated that only 10 % of the mice will cost. Praying Hugo Belle from Beller College, “You get 10 times more organisms for the dollar in the bees than you meet in mice,” with the same high effects, we will add.
To avoid high costs of regulatory obstacles and In the Vivo Experienced with adventurers, many scientists seek refuge in cell culture models, which have several boundaries. We have recently collected cost data from independent suppliers in Brazil to assess the annual cost of establishing and running a fly lab compared to the cell culture lab. The results can be found here. We found it Druzofla Culture is almost three times less expensive than mammalia cell cultures. If we only consider unbearable items, the annual costs are about seven times less (as seen in graphic 1).
We have based our estimates based on advanced fly lab materials and equipment, so cost differences can be even higher with lower -level infrastructure or “domestic” devices. For example, we can now make our own partner2 Compared to those sold by pads, which is used to anesthesia (adult flies), on a part of the cost, compared to those sold. We are also currently examining a mild emission system for the screening of the GFP-positive bees, which competes with the Royal Blue of Nitis.
Researchers receiving new services will potentially get a cell culture laboratory or mouse/rat facility in their institutions, which minimize initial costs. However, in a long time, working with these models can be expensive and administratively burdened with the need for approval of the Ethics Committee.
With DruzoflaWe run genetic and toxic screens, model neurodegence and cancer, development and metabolism. In the VivoAnd follow the multilateral effects with these tools that rivals (or ahead) of those used in more expensive systems. It is a deep biology in a whole animal, on a part of the cost – and here is available in our own country.
In Brazil, especially young researchers are often said to think big, but do small things. Most of our federal grants are small, and our post dockles and grade students pay less salaries (State Sao Paulo is an outlet, as the State Foundation is committed to funding FAPESP science). The same Druzofla There may be a career -keeping choice. This allows the new labs to publish meaningful results, train students in a strict way and build international support, without the anxiety of getting out of the middle experience without supplying any goods.
Culture, impression, and financing priorities
A barrier is a local impression that Druzofla Research is equal to genetics and evolutionary research. It is true that fruit bee research has had a huge impact in these areas around the world in the last century, but contemporary Druzofla The research is high. Here are thousands of transgender fly lines that literally serve as “living Regents” and costs US $ 28. Their use allows us to combine modern tools and classical genetics in numerous biological issues.
We need to deny how we think about high quality and cost efficient science. Money saving in an area (a cheap but so effective model using biology as Druzofla) Somewhere else frees resources to ask bold questions. This allows duplication, repetition, and expansion.
We have seen colleagues illuminate when they realize that they can examine a new assumption in the days, not in months, and students have been enabled to study Parkinson’s or Alzheimer’s disease in a small fly, because they also have a complex nerve circuit. For many of them, Druzofla Discovering can be his first real opportunity to engage in science.
Flying infrastructure – and confidence
The cost alone does not guarantee success. Druzofla Work can be diligent and still require trained personnel and facilities. Combined flyrooms, stock maintenance support, and national reservoirs can reduce obstacles in dramatic way dramatically Druzofla In Brazil, we are part of a growing fly community interested in biomedical research, known as the fly power group. We are practically once a month and once a year.
We are engaged in outreach programs, scientific, training courses and fly research advocates. In May, we personally held a two -day Person Fly Power meeting before the annual meeting of the Brazilian Society for Biochemistry and Molecular Biology, during which we also presented a course. Druzofla Genetic tools. In July, during the annual meeting of the Brazilian Federation of Experimental Biology Societies, we had another way. Last year, the XI symbolism of environment, genetics and evolution Druzofla With the presence of many members of the fly power, dedicated a complete session on biomedical use of bees. And finally, the company using the first starting company in the country last year Druzofla The functional genomic test was launched.
Is also committed to bringing fly power Druzofla In diverse undergraduate classrooms. Our aim is to highlight its compatibility in many areas of biomedical sciences, including biochemistry, physiology, cell biology, and more. The move helps to make young students more aware Druzofla And its powerful genetic tool cut. We are determined to continue until more researchers are given the option to integrate both their lab routines and teaching methods.
A model for equity and durability
The ultimately, Druzofla Not just the cost of savings. It is a powerful platform for democratic science. It opens the door to the labs, otherwise it will be priced by biological research. In a country like Brazil, where brilliant scientists and creative ideas often go into the walls of the budget, it makes a difference. Even this can be relevant to avoid the emergence of young brains from the country, which is attracted to the global north in search of better career prospects.
Druzofla Research also brings environmental stability. Animals can be developed in small glasses/plastic bottles that can be cleaned and reused, which is different from the culture of cells. In the vitroWhich produce a certain amount of plastic. And glass utensils time demand, to overcome manual cleaning, limited factor in scaling Druzofla Culture, we are working on the design of new equipment that can also save water and soap.
By embracing models that make our work more sustainable and equally efficient, we can create research programs that are flexible and globally relevant. In this way, a small bee can help increase Brazil’s life studies. It’s time to fly!
