The use of antibiotics can have the effects of knocking on the immune system
Citizens/Alami
According to a study of more than 60 million children, children who are exposed to antibiotics in the uterus or in early life are usually not at risk of developing self -esteem. But the relationship is complicated.
The idea that antibiotics can play an important role in automatic force, can be detected by the 1980s, when David Strachchin, then at the London School of Hygiene and Tropical Medicine, suggested that low infections and clean environment explains childhood allergies.
This led to the development of hygiene speculation. It has been suggested that the initial exposure of some microbes trains the immune system, and prevents it from abusing harmless substances and causes allergic reactions or autoimmune conditions. These conditions, such as type 1 diabetes, inflammatory intestinal disease and leuops, are found when immune cells inadvertently attack the body’s tissues.
Since then, numerous studies have shown that many germs – especially in our courage – create our immune system. For example, some compounds produce compounds that are essential for the development of special immune cells, called regulatory T cells, which help to avoid automatically. As a result, there have been questions as to whether antibiotics, which significantly change the gut micro -biomet, can help in the development of autoimmune conditions.
“Over the past years, many pre -clinical works have been done, in most animal models, which supports the idea that antibiotics, or gut micro -biome edit, has a huge impact on our immunity,” says Martin Crelegel at the University of Germany of Germany.
For example, a 2016 study in mice has shown that repeated use of antibiotics in early life increases the risk of type 1 diabetes. The rats were genetically subjected to this condition. Once his mother’s milk came and then came to an antibiotic at the age of 4 and 5 weeks. In this group, about 50 % of male mice and 80 % of female mice developed type 1 diabetes at the age of 30 weeks. In comparison, only 25 % of male rats and 50 % of women who did not appear to be mice, which did not appear to be the antibiotics, developed this condition.
Human studies have also indicated a link. An analysis of more than 10 million people published earlier this year has shown that these antibiotics are at an average of 40 % higher risk, which is later diagnosed with inflammatory intestinal disease. Meanwhile, a 2019 study of more than 110,000 people has revealed that antibiotic prescriptions are associated with 60 % more likely to promote rheumatoid arthritis.
But other research has shown the opposite. For example, more than 15,000 children tested for type 1 diabetes or silicic disease have not been associated with the development of these conditions and the use of antibiotics before the age of 4.
Recently, Yun-Ying Choi and his colleagues at the University of Sangkonkovan, South Korea, had six autoimmune conditions-Type 1 diabetes, chronic childhood arthritis, ulcerative colitis, crop disease, Loopos and Hashmoto disease. About 1.5 million mothers were proposed to be antibiotics during their pregnancy. Researchers then did the same in a separate group of 3.4 million children, who had an infection within six months of birth, of which 1.9 million were treated with antibiotics.
After calculating the factors such as infection, socio -economic status and gender, researchers did not find the risk of exposure to children from uterus or antibiotics in early childhood and later in youth.
So why is there so much contradiction between the study? The problem is, gut microbium is extremely complicated. Different types of factors affect this, which makes it almost impossible for researchers to calculate them all. For example, none of the aforementioned studies have been adjusted to the diet, which cannot significantly change the Gut Microscope.
Different antibiotics can also have different effects. For example, Choi and his team searched an association between the use of wide spectrum antibiotics during pregnancy and later on children who are caused by Crohn’s disease. Participants’ exhibition also makes a difference in age. Of which, within two months, antibiotics were at 30 % higher risk of Hashimoto disease.
This does not mean that we should abandon antibiotics. In the American College of Ogestrins and Gynecologists in Washington DC, Christopher Zahan, about Christopher Zeen, “When recommending antibiotics in pregnancy, is because the evidence shows that the benefits are far more than possible risks.” For example, urinary tract infections increase the risk of premature birth, low birth weight and serious complications, such as sepsis.
Some antibiotics can even protect against autoimmune. A 2018 study found that infection with pathogenic bacteria Intercomox gallonram Automatic autoimmune was mobilized in mice suffering from such conditions. Treating them with antibiotics not only prevented them from dying, but their immune cells were also prevented from attacking their body.
“So it’s all very complicated,” says Cragiegal.
Yet, the recent results should be assured of antibiotics that are pregnant or young children.
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