How do the cells unite in the fetal

Detecting the destiny of individual fetal stem cells, researchers have found that endodram cells-fetal cells that give rise to tissues like gut and lungs.

When you plan a trip, it is rare that you do not have the choice. One can be more straight, the other can be more beautiful. But regardless of time or path, the destination is the same. This concept of pathways that converted into development biology can also be observed, even in the paths that specialize in fetal cells.

As the Creek Group leader, Silvia Santos, describes, “In the early development, during a phase called gastroes, a layer of fetus is transformed into a multi -layered structure. Three layers of cells, known as layers of germs, are known as the body’s nutrients.

“But how the germs layers have been the subject of disagreement among scientists. In particular, scientists have not concluded how the cells specialize to be part of the endodram, which is the inner layer and many important internal organs, including guts, liver and lungs.”

Route to the map

Several models of cell destiny lineage have been presented, some researchers have suggested the “traditional” straight path, where the steam cell guidance is gradually and gradually limited through indicator indicators. Others have suggested a more dynamic model, where the fate of the cell is more flexible and subject to real -time positioning and indicators, which means that a cell can reach Endoderm’s fate through another development path.

In the new research published today Development CellSantos team, to track the destiny of the cell and determine which of these routes is right.

He found that there was no only way here, and these ideas were not competitive explanations, but was the complementary snapshots of human development. He has provided a combination model for a long -standing debate that is compatible with the contradictory models of Mesodram and Endoderm’s specification – somehow, everyone was fine.

Forward

The team also witnessed the influence of two major signaling molecules, activities and BMP4, which did both work together and in competition to find out which path to the cells.

“We witnessed specific time windows when the cells were responsible for these gestures,” Oli Angi said, which leads to this study. “During this period, the concentration of them has determined which path to the cells, as the SAT Navy determines what way is to go based on current traffic advice.”

The INNE identified BMP4 as a major driver of the cell lineage, as the relative detention in its activities was directly important by the Endoderm specialist or in the steering cells by the Mesodram state.

The mystery remains why cells can take different paths to the same destiny, especially when some paths look more straight.

“We think it is a sign of how important the development phase is.” “Failure to distinguish the layers of germs during gastriclation is a significant assistant in the loss of pregnancy and without the proper formation of the endodram layer, after which important internal organs will not be formed from the branches. Therefore, the exchange of these cell tissues provides a strong foundation for our development.”

“In fact, the population of the early cells is so important that they are considered to be the sacred stone of the re -born medicine because they are able to effectively derive in the lab, and it brings a step closer to us.”

“When we have addressed some important questions about our initial development, we have further highlighted the complexity of cell fate decisions.”

“It was just an inter -formal approach – together with the transcript (transcript) Omix, mathematics and imaging techniques that we can understand, at an individual cell level, how the fetal cells choose their fats and expose key blueprints for early growth.”